Management of areas invaded by cheatgrass (Bromus tectorum) continues to be one of the greatest challenges for US Great Basin ecosystems. Targeted cattle grazing in the fall and winter has shown positive results as a management tool to reduce dormant fine fuel biomass within cheatgrass-invaded areas, but management of targeted grazing within large pastures can be challenging. We evaluated the use of strategically placed liquid protein supplement stations over a 4-wk period in the fall to focus cattle grazing along a linear transect stretching away from water to reduce residual cheatgrass biomass on a production-scale, working ranch from 2014 to 2017. Liquid protein supplement stations were moved approximately 1 km farther from water during each week of the study, eventually reaching 4 km from a single water source. Global Positioning System–tracked cattle visited supplement stations 52% ± 4% of the days during the study period and were within 100 m of the supplement station transect line 17.7% ± 2.6% of the time: more than 3 × greater (P= 0.07) than random locations (5.1% ± 2.6%). Week of the study and the subsequent supplement distance from water did not influence the number of visits cattle made to supplement. The duration that cattle remained at supplement was greater in wk 4, when supplement was placed 4 km from water, compared with wk 1 and 2, when the supplement was 1 and 2 km from water, respectively. At the conclusion of grazing, utilization along the supplement station transect averaged 66.0% ± 5.7% and did not differ between supplement stations at 1 km, 3 km, or 4 km from water. Strategic supplementation provides a valuable tool to target cattle grazing at specific locations within cheatgrass-invaded systems to reduce fine fuel buildup during the dormant season.