Four new species of Eleutherodactylus are described from montane forests at elevations of 1330–3000 m in the Cordillera Oriental in the central Peruvian Departamentos Huánuco, Junín and Pasco, Three of the new species are assigned to the Eleutherodactylus unistrigatus Group. Two of them lack a tympanum, but have distinct colorations and iris patterns: one has the groin and hind limbs partly orange to red and the iris with a brown vertical and black horizontal streak forming a cross, whereas the other has the groin and hind limbs partly yellow and the iris with a brown horizontal streak and a black vertical streak from the pupil to the lower margin of the eye forming a “T”. The third species, assigned to the Eleutherodactylus conspicillatus Group, is similar to E. rhabdolaemus, but differs from that in certain morphological characters and coloration. The fourth species, assigned to the E. lacrimosus assemblage, has a yellowish-tan dorsum with dark brownish-purple blotches and streaks and white flanks and venter. It inhabits terrestrial bromeliads and is compared with E. schultei from northern Peru. Morphological and distributional data are provided for seven previously described Eleutherodactylus from central Peru. The elevational distributions of Andean Eleutherodactylus, Phyllonastes, and Phrynopus from central Peru is compared.