Hoof and mouth disease is a potentially serious threat to the agricultural industry of the state of Kansas. Although not invariably fatal in humans or animals, its zoonotic properties, ease of spread, and rapid mutation into vaccine-resistant forms make it a major concern. Geographic Information Systems (GIS) have proven useful towards the containment and eradication of outbreaks globally. Although situations differ, GIS functionality has contributed to meeting various objectives. The state of Kansas utilizes GIS for a variety of emergency management situations. A suggested set of objectives and GIS procedures for responding to an outbreak provides a fundamental approach for consideration. Through the incorporation of the geodatabase structure, geoprocessing, and raster spatial analysis, a more effective response to a hoof and mouth disease outbreak may be achieved.