I describe an Eastern Screech-owl (Megascops asio) hatching three Wood Duck (Aix sponsa) eggs in a suburban nest box. Wood Duck(s) removed all five eggs of a completed screech-owl clutch, the earliest of which had already been incubated for at least 19 days, and laid three eggs in their place. The female screech-owl hatched the Wood Duck eggs, preened the ducklings, and attempted to feed them until they exited the nest box within 48 hrs of hatching.