The Prioninae (Cerambycidae) of Hispaniola are reviewed. Twenty-eight species are known from the island, including six new species and a new genus described herein: Elateropsis dichroma Lingafelter, new species, Elateropsis woodleyi Lingafelter, new species, Solenoptera tomentosa Lingafelter, new species, Solenoptera helbi Lingafelter, new species, Solenoptera rugosa Lingafelter, new species, and Derancistrachroma melanoleuca Lingafelter, new genus and new species. Derancistrus furfurosus Galileo and Martins, 1993 is transferred to Solenoptera Audinet-Serville, 1832 as S. furfurosa, new combination; the holotype is determined to be a female, and the male is described for this species. Derancistrodes vittatus (Olivier, 1795) is transferred to Solenoptera as S. vittata, new combination, and Derancistrodes Galileo and Martins, 1993 is a new synonym of Solenoptera. New country records are recorded for Strongylaspis corticarius (Erichson, 1848), Monodesmus atratus Fisher, 1932, Elateropsis quinquenotatus Chevrolat, 1862, Elateropsis sericeiventris Chevrolat, 1862, and Elateropsis trimarginatus (Cazier and Lacey, 1952). The first known female of E. trimarginatus is described. Diagnoses and discussions are provided for each species. A key to all the Prioninae known from Hispaniola is included.