To deeply reach target markets and attract more tourists, a variety of media have been leveraged by tourism destination marketing organizations, particularly video games become a brand-new approach for destination marketing. With Assassin's Creed: Unity as the research object, based on the Stimulus-Organism-Response (SOR) model, this article analyses and presents the influences of tourism destination factors in video games on the players' perception of tourism destination image and their intention to visit. In this case, a conceptual model has been built with game factors as the independent variable, tourism destination image as the mediating variable and the players' intention to visit as the dependent variable. Moreover, Multiple Regression is used in the analysis, proving significantly positive effects of game experience, character attachment, and tourism destination image on players' intention to visit. Consequently this study provides research support for the combination of tourism destination marketing and video games.