A 10-year-old, green-cheeked conure (Pyrrhura molinae) was examined because of weight loss and neurologic signs referable to a focal left cerebral lesion. The clinical signs did not improve with treatment, and the animal was euthanatized for humane reasons. A primary brain tumor involving the left cerebrum was found at necropsy. On the basis of histologic morphology and results of immunohistochemical staining of the tumor, the diagnosis was malignant astrocytoma with features of glioblastoma multiforme.