Centaurea osmaniyensis İlçim (Asteraceae) sp. nova is described and illustrated from Bahçe District, Osmaniye Province, Turkey. The species belongs to sect. Cynaroides and morphologically closely resembles C. regia var. cynarocephala, but differs from it by the habit, petiolate leaves, stem and leaf indumentum, capitulum shape, phyllary length, appendage size, terminal spine length and pappus color. The seed and pollen micromorphology are presented, as well as the threat level is evaluated.