Concrete domestic water-storage jars are a common larval habitat of the dengue vector Aedes aegypti in countries of Southeast Asia. The efficacy of a novel controlled-release formulation of the insect growth regulator pyriproxyfen, designed to inhibit adult emergence for 6 months (the approximate duration of the main dengue transmission season in many endemic countries) was tested in Cambodia against a local strain of Ae. aegypti in 200-liter jars. The resin-based formulation contained 4.8% active ingredient (AI). At target dosages of 18, 27, and 36 ppb of AI, inhibition of adult emergence remained above 95% for at least 2 months. After 3 months at 18 ppb AI, the residual efficacy was significantly lower than for the higher dosages (P < 0.05). At the higher dosages, inhibition of adult emergence was ≥87% for 6 months. At a dosage of 27 ppb AI, monthly removal and replacement of two thirds of the water did not reduce efficacy (P > 0.05). Potential operational advantages and challenges of using the formulation are discussed. Larger-scale efficacy studies are recommended in community settings.
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1 March 2006
INHIBITION OF ADULT EMERGENCE OF AEDES AEGYPTI IN SIMULATED DOMESTIC WATER-STORAGE CONTAINERS BY USING A CONTROLLED-RELEASE FORMULATION OF PYRIPROXYFEN
CHANG MOH SENG,
TO SETHA,
NGAN CHANTA,
DUONG SOCHEAT,
PIERRE GUILLET,
MICHAEL B. NATHAN
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Journal of the American Mosquito Control Association
Vol. 22 • No. 1
March 2006
Vol. 22 • No. 1
March 2006
Aedes aegypti
household water-storage jars
larvicide
pyriproxyfen