Collection of specimens of the Neotropical weevil genus Coptonotus Chapuis in Ecuador led to the discovery that Coptonotus cyclopus Chapuis, 1869 was comprised of multiple species. Parsimony analysis of morphological and molecular characters produced a well-supported phylogeny of seven Coptonotus specimens, which contained morphologically diagnosable monophyletic groups. Two new superficially similar species are described: Coptonotus doppelganger Smith and Cognato, new species from Peru and Brazil, and Coptontous uteq Smith and Cognato, new species from Ecuador. Coptonotus uteq was collected from a host tree, providing the first report of the natural history of the genus. Larvae are described for the first time. A key to the species is presented, and the relationship of Coptonotinae to other weevil subfamilies is discussed.