The efficacy of meso-dimercaptosuccinic acid (DMSA) (succimer) in treating avian lead intoxication was studied in a retrospective, nonrandomized, longitudinal study. Nineteen birds with moderate to high blood lead concentration and neurologic signs compatible with lead toxicity were treated with DMSA (30 mg/kg p.o., b.i.d.; n = 15) for a minimum of 7 days. In cases with severe neurologic signs, DMSA was supplemented with a single dose of edetate calcium disodium (<50.0 mg/kg of body weight i.m.; n = 4). Blood lead concentrations were measured two or more times (before and after treatment). Median blood lead concentration decreased (87%), neurologic signs were resolved, and there were no apparent adverse secondary effects.
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1 March 2003
ORAL TREATMENT OF AVIAN LEAD INTOXICATION WITH MESO-2,3-DIMERCAPTOSUCCINIC ACID
Almira L. Hoogesteijn,
Bonnie L. Raphael,
Paul Calle,
Robert Cook,
George Kollias
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Journal of Zoo and Wildlife Medicine
Vol. 34 • No. 1
March 2003
Vol. 34 • No. 1
March 2003
birds
DMSA
lead toxicity
meso-dimercaptosuccinic acid
succimer