We have initiated efforts to determine the molecular basis for the M^D meiotic drive system in the mosquito, Aedes aegypti. The effect of the M^D gene is a highly male-biased sex ratio, but varies depending on the frequency and sensitivity of a susceptible responder m^s allele. The M^D system has potential as a mechanism for driving trangenes for pathogen resistance into natural Ae. aegypti populations. Because all previously existing laboratory strains carrying the M^D gene have been lost, we have selected for a new strain, T37, that carries a strong driver. Matings between T37 males and drive-susceptible m^s females result in progeny with highly biased sex ratios, wherein only ≈14.7% females are produced. We discuss the potential for identifying M^D candidate genes based on comparisons with the well-described Drosophila melanogaster segregation distorter (SD) meiotic drive system and considerations for release of transgenic Ae. aegypti into natural populations where M^D and insensitive mⁱ alleles are likely segregating.