Radiation exposures from accidents, nuclear detonations or terrorist incidents are unlikely to be homogeneous; however, current biodosimetric approaches are developed and validated primarily in whole-body irradiation models. A workshop was held at the Armed Forces Radiobiology Research Institute in May 2008 to draw attention to the need for partial-body biodosimetry, to discuss current knowledge, and to identify the gaps to be filled. A panel of international experts and the workshop attendees discussed the requirements and concepts for a path forward. This report addresses eight key areas identified by the Workshop Program Committee for future focus: (1) improved cytogenetics, (2) clinical signs and symptoms, (3) cutaneous bioindicators, (4) organ-specific biomarkers, (5) biophysical markers of dose, (6) integrated diagnostic approaches, (7) confounding factors, and (8) requirements for post-event medical follow-up. For each area, the status, advantages and limitations of existing approaches and suggestions for new directions are presented.
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1 February 2010
Synopsis of Partial-Body Radiation Diagnostic Biomarkers and Medical Management of Radiation Injury Workshop
Pataje G. S. Prasanna,
William F. Blakely,
Jean-Marc Bertho,
John P. Chute,
Eric P. Cohen,
Ronald E. Goans,
Marcy B. Grace,
Patricia K. Lillis-Hearne,
David C. Lloyd,
Ludy C. H. W. Lutgens,
Viktor Meineke,
Natalia I. Ossetrova,
Alexander Romanyukha,
Julie D. Saba,
Daniel J. Weisdorf,
Andrzej Wojcik,
Eduardo G. Yukihara,
Terry C. Pellmar
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