Linkage Disequilibria and Haplotype Structure of Four SNPs of the Interleukin 1 Gene Cluster in Seven Asian Indian Populations

Srilakshmi M. Raj; Ranajit Chakraborty; Ning Wang; Diddahally R. Govindaraju

doi:10.1353/hub.2006.0026

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Srilakshmi M. Raj,^* Ranajit Chakraborty,^** Ning Wang,^*** Diddahally R. Govindaraju^*,****

^*St. John's College, Oxford University, Oxford, United Kingdom OX1 3JP.
^**Center for Genomic Information, Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, OH 45221.
^***Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229.
^****Present affiliation: Department of Neurology, Boston University School of Medicine, Boston, MA 02118.

Abstract

Variation at four single nucleotide polymorphism (SNP) sites of the interleukin 1 (IL1) gene cluster was investigated among 280 unrelated individuals, representing 7 caste groups from the state of Karnataka, India, and one European American community of Boston, Massachusetts. Allele and haplotype frequencies, strength of linkage disequilibrium, and signatures of recombination varied considerably among populations. Variable community sizes and traditions of consanguinity may account for the observed variation.

Citation Download Citation

Srilakshmi M. Raj, Ranajit Chakraborty, Ning Wang, and Diddahally R. Govindaraju "Linkage Disequilibria and Haplotype Structure of Four SNPs of the Interleukin 1 Gene Cluster in Seven Asian Indian Populations," Human Biology 78(1), 109-119, (1 February 2006). https://doi.org/10.1353/hub.2006.0026

Received: 11 April 2005; Accepted: 1 August 2005; Published: 1 February 2006

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